李俊,金柏峰,义祥辉

• 1:广西师范大学资源与环境学系
• 2:广西师范大学资源与环境学系
• 3:桂林师范高等专科学校化学系 广西桂林541004
• 4:广西桂林541004

摘要(Abstract)：

介绍了国内外对脯酰肽内切酶 (PEP)抑制剂的最新研究进展 .

关键词(KeyWords)： 脯酰肽内切酶;抑制剂;化学成分

Abstract:

Keywords:

基金项目(Foundation): 教育部重点基金资助项目 (No.0 194) ;; 广西自然科学基金资助项目 (桂科基 0 14 40 2 5 )

作者(Author): 李俊,金柏峰,义祥辉

参考文献(References)：

• [1]　李俊,范文哲,义祥辉.人工种植高山红景天中抑制Prolyl-Endopeptidase的化学成分[J].中草药,2004,35(8):852-854.
• [2]　Yoshim otoT,SimmonsW H,NishimuraT,et al.Post- proline cleaving enzyme(pro1y1endopeptidase) from bovine brain[J].J.Biochem,1983,94(10):1179-1190.
• [3]　OdakaC,MizuochiT,ShirasawaT,etal.MurineT cells expressing high activity of pro1y1endopeptidase are susceptible toactivation indduced cell death[J].FEBS letters,2002,512(1):163-167.
• [4]　IrazustaJ,F.SilveiraP,GilJ,et al.Effects of hydr- osaline treatments on prolyl endopeptidase activity in rat tissues[J].RegulatoryPeptides,2001,101(1):141-147.
• [5]　MaesM,L ibbrechtI,L inA H,et al.Effects of pregnancy and delivery on serum pro1y1endopeptidase(PEP) activy:alterations in serumPEP are related to increased anxiety in the early puerperium and to postpartum depression[J].JAffectiveDisorder,2000,57(1):125-137.
• [6]　HermeczI,KanaiK.Pro1y1endopepitidase inhibitors[J].IlFarmaco,2000,55(2):188-190.
• [7]　MaesM,MonteleoneP,BencivengaR,et al.L ower sem m activiy of pro1y1endopeptidase in anorexia and bulimia nervosa[J].Pschoneuroendocrinology,2001,26(1):17-26.
• [8]　Fruitier-ArnaudinI,CohenM,CoitiouxC,etal.In vitro metabo1ism ofL VV-Hemorlphin-7by renal cytoso1and puhnedpro1yl endopeptidase[J].Peptides,2003,24(6):1201-1206.
• [9]　MowatA M.Coeliac disease- a meeting point for genetics,immunology,and protein chemistry[J].TheL ancet,2003,361(4):1290-1292.
• [10]　KatsuoToide,MasahikoAhinoda,et al.A novel prolyl endopeptidase inhibitor,JTP-4819,with potential for treatingAlzheimer'disease[J].BehaviouralBrainResearch,1997,83:147-151.
• [11]　NaoyoshiMiuraShigenobuShibata,et al.Z-321,a prolyl endopeptidase inhibitor augments the potentiation of synaptictransmission in rat hippocampal slices[J].BehaviouralBrainResearch,1997,83:213-216.
• [12]　YoshiYukiShishidoMasayoshiFurushiro,et al.ZTTA aPostprolineCleavingEnzymeInhibitor,ImprovesCerebralIschemia-InducesDeficitin aThree-PanelRunwayTask in rats[J].PharmacologyBiochemistry&Behaviour,1996,55(3):333-338.
• [13]　IstvánHermeczKárolyKánai.Prolyl endopetidase inhibitors[J].IL ,Farmaco,2000,55:188-190.
• [14]　WenzheFan,Yasuhiro,TEZUKAProlyl,et al.EndopeptidaseInhibitors from theUndergroundPary ofRhodila sacraS.H.FU .Biol[J].Pharm.Bull,1999,22(2):157-161.
• [15]　MizueOhsugi,WenzheFan,et al.Active- oxygen scavenging activity of traditional nourishing- tonic herbra medicines andactive constituents ofRhodiola sacra[J].Journal ofEthnopharmacology,1999,67:111-119.

文章评论(Comment)：